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All cancer patients in drug trial appear to be cured for ‘first time in history’

An experimental cancer drug appears to have cured every single patient in a small clinical trial conducted in the US.

All 12 patients, who had been diagnosed with rectal cancer, entered into remission after taking dostarlimab over a six-month period, according to a study published in the New England Journal of Medicine.

“This is the first time this has happened in the history of cancer”, Dr Luis Diaz, one of the lead authors of the paper and an oncologist at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York, told The New York Times.

The patients also experienced no significant side effects during the course of their treatment, though it’s believed not enough people were involved in the study to highlight the different adverse reactions caused by the drug.

Although excited by the research, scientists have said the promising results will need to be repeated, and cautioned against concluding whether the patients had been cured of their cancer. Dostarlimab is an immunotherapy drug used in the treatment of endometrial cancer, but this was the first clinical investigation of whether it could be effective against rectal cancer tumours. The drug works by unmasking cancer cells, allowing the immune system to identify and destroy them. For the research, the 12 patients received dostarlimab every three weeks for six months. This treatment was to be followed by standard chemoradiotherapy and surgery. However, six months after the patients stopped taking the medication, their cancer had vanished, being undetectable by physical exam, endoscopy, PET or MRI scans. Two years on from the study, the patients appear to remain cancer-free, and not a single participant from the trial has yet to receive chemoradiotherapy or undergo surgery. Dr Hanna Sanoff, of the University of North Carolina, who was not involved in the study, said the research was “small but compelling”. “These results are cause for great optimism,” she wrote in an editorial accompanying the paper, adding that the research has “provided what may be an early glimpse of a revolutionary treatment shift”. However, she cautioned, “such an approach cannot yet supplant our current curative treatment approach” and said it remains unclear if the patients are cured. “Very little is known about the duration of time needed to find out whether a clinical complete response to dostarlimab equates to cure,” Dr Sanoff wrote. In separate comments, Dr Sanoff explained that dostarlimab is a type of drug called an immune checkpoint inhibitor. These are immunotherapy medicines that work not by directly attacking the cancer itself but actually getting a person's immune system to essentially do the work,” she told NPR. “And these are drugs that have been around in mela noma and other cancers for quite a while but really have not been part of the routine care of colorectal cancers until fairly recently.” All of the 12 patients in the study had tumours with genetic mutations called mismatch repair deficiency (MMRd), seen in a subset of approximately 5 to 10 per cent of rectal cancer patients. Patients with such tumors tend to be less responsive to chemotherapy and radiation treatments, which increases the need for surgical removal of their tumors. However, MMRd mutations can also make cancer cells more vulnerable to immune response, especially it's bolstered by an immunotherapy agent – in this case, dostarlimab. Dr Kimmie Ng, a colorectal cancer expert at Harvard Medical School, told The New York Times the results were “remarkable” and “unprecedented,” but said they would need to be repeated. Credits: New England Journal of Medicine Belfast Telegraph

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